Corpus of biochemical changes after death by potassium intoxication in rabbits / 法医学杂志

OBJECTIVE@#To explore the objective evidence of the corpus biochemical changes in rabbits for postmortem diagnosis of potassium intoxication.@*METHODS@#Rabbits were sacrificed by Infusion of 0.3% KCl at full speed push or 1% KCl at 100 drip/min, respectively, with normal rabbits used as control. Cardiac blood and urine samples were collected before and after potassium infusion to examine the concentrations of various electrolytes (K+, Na+, Ca2+, Mg2+, Cl-, and HCO3-) and to observe the antemortem and postmortem biochemical changes.@*RESULTS@#The mean lethal infusion time in the 0.3%KCl group was longer than that in the 1% KCl group (P = 0.006). The serum concentration of K+ increased while the serum concentrations of Na+, Ca2+, Cl-, and HCO3- decreased after the infusion. There were no statistically significant differences in the whole blood concentration of K+ as well as the serum concentration of Mg2+ between the two groups (P = 0.062). There were statistically significant differences in the concentrations of whole blood K+, as well as serum Na+, Mg2+, and Cl-, but not in the serum K+, Ca2+, and HCO3-. There were no statistically significant differences seen in the urine volumes and the concentrations of all the urine electrolytes between the groups.@*CONCLUSION@#Examination of the concentrations of K+ both in the whole blood and serum, as well as Mg2+ in the serum may be helpful for postmortem diagnosis of potassium intoxication.

Morphological changes in rabbits died of potassium intoxication / 法医学杂志

OBJECTIVE@#Morphologic features of the corpse of rabbits died of potassium intoxication were studied in order to elucidate an objective evidence for forensic determination of death caused by potassium intoxication.@*METHODS@#Macroscopic, microscopic, and ultrastructural (by transmission electron microscopy) changes were observed in the heart, brain, and kidney of rabbits killed by intravenous push or continuous infusion at 100 drips per minute with 0.3% and 1% KCl, respectively. Normal rabbits without any treatment killed by bleeding were used as controls.@*RESULTS@#Macroscopically, cardiac dilatation and congestion/stasis as well as ischemic and hypoxic changes in various organs were observed in rabbits died of potassium injection. Microscopically and ultrastructurally, there were destruction of the cardiac fibers with thickening, concentrating, or disappearing of the Z-line, constriction of the glomerular capillaries, enlargement of the Bowman capsule, thinning and fusion of foot processes, as well as apoptosis with phagocytosis in brain observed, particularly in the group infused with 1% KCl.@*CONCLUSION@#The morphologic changes observed in the heart and kidney appear to be characteristic, supporting death caused by potassium intoxication.

Pico de fluxo expiratório em trabalhadores de fábricas de fogos de artifício / Expiratory peak flow in employees of firework factories

A pólvora é uma mistura explosiva constituída por 75 por cento de salitre (nitrato de potássio), 12 por cento de carväo e 13 por cento de enxofre, moídos em conjunto. O objetivo deste trabalho foi verificar um possível acometimento das vias aéreas de trabalhadores de fábricas de fogos de artifício por pólvora inalada. Foram medidos os picos de fluxo expiratório de 234 pessoas do Município de Santo Antônio do Monte, Minas Gerais: 41 sem exposiçäo profissional à pólvora (grupo controle) e 193 trabalhadores de fábricas de fogos de artifício. Os parâmetros utilizados foram: idade, sexo, estatura, peso, tabagismo e tempo de exposiçäo à pólvora. Todos os indivíduos pertencentes ao grupo controle tiveram seus níveis de pico de fluxo expiratório dentro da normalidade. Em 50 (25,9 por cento) trabalhadores houve reduçäo desse fluxo, sendo que 34 (68 por cento) eram tabagistas, 10 (20 por cento) tinham entre 5 e 10 anos de exposiçäo e 10 (20 por cento) tinham mais de 10 anos de exposiçäo. Concluindo, a pólvora parece ser um fator relacionado à reduçäo de pico de fluxo expiratório, principalmente em indivíduos tabagistas.

study of gastric acidity, mucus, serum gastrin and iron in post postach patients with chronic gastric affection

Gastric acidity, mucus, serum gastrin and iron were studied in fifteen post potash patients. Biopsies were obtained from the fundus and body of the stomach during the procedure of gastrostomy to prove corrosive gastric affection due to potash poisoning. The study included also fifteen volunteers as controls. The results indicated significant hypoacidity and decrease in gastric mucus in post potash patients compared to controls and this was attributed to gastric histopathological changes in the form of chronic inflammation, fibrosis and glandular distortion. On the other hand, serum gastrin was significantly higher in patients compared to controls and this increase might be due to hyperplasia of the antral G-cells and hypoacidity in those patients. Serum iron showed significant decrease level in post potash patients compared to controls and this was attributed to decrease in gastric absorption due to evidenced gastric histopathologic changes and hypoacidity in those patients

Acute Renal Failure due to Potassium Bromate Poisoning

Poisoning due to potassium bromate, cold wave neutralizer for permanent waving solution in hair styling, is rarely encountered and only few cases are as a cause of acute renal failure reported in medical literature. Recently, we saw a 18 year-old-female patient, hair stylist, who was admitted to Severance Hospital due to acute renal failure after accidental ingestion of potassium bromate. This is the first known case of acute renal failure due to potassium bromate poisoning in Korea.